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2024

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The choice of the type of salt in the peptide custom product process is important!


The salt types of polypeptide products not only affect the solubility and stability of polypeptides, but also have partial biotoxicity. So choosing the right type of salt is crucial to the success of the experiment. The types of salt that Supertide can provide are

Salt type

Characteristics or uses

TFA

Polypeptide products are usually trifluoroacetate. Because of the high biotoxicity of trifluoroacetic acid, this salt type should be avoided in some experiments.

Ac

Because of the low biotoxicity of acetic acid, most drug peptides or beauty peptides are acetate. However, the acetate stability of some products is not good, so the sequence stability should be considered.

HCl

Less products will choose the hydrochloride. Some sequences require the use of hydrochloride for specific purposes

NH4+

It will seriously affect the solubility and stability of the product, which needs to be selected according to the sequence.

Na+

This usually affects the solubility and stability of the product

Pamoic acid

Dihydroxynaphthenate is commonly used in the production of peptide drugs as a sustained-release agent

Citric Acid

Biotoxicity is relatively low, but due to the complexity of the preparation process, it is necessary to develop the production process separately according to the sequence

Salicylic acid

Affect the stability of polypeptide products, less used

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