What are peptides? A brief history of peptide development

Polypeptide in recent years in the pharmaceutical chemical, food chemical, skin care, biotechnology and other industries shine. Be widely concerned and valued by all walks of life! So what are peptides?

A polypeptide is a compound of -amino acids joined together by peptide bonds and is an intermediate product of proteolysis. Compounds formed by the dehydration and condensation of two amino acid molecules are called dipeptides, and similarly there are tripeptides, tetrapeptides, pentapeptides, and so on. A compound usually formed by the dehydration and condensation of 10 to 100 amino acids is called a polypeptide. Proteins are sometimes called polypeptides. Peptides, also known as peptides for short, were discovered in the 20th century. There are two kinds of peptides: bioactive peptides and synthetic peptides.

Many of the body's active substances are in the form of peptides. Peptides are involved in various fields of human hormones, nerves, cell growth and reproduction, and their importance lies in regulating the physiological functions of various systems and cells in the body, activating relevant enzymes in the body, promoting the permeability of intermediate metabolic membrane, or finally producing specific physiological effects by controlling DNA transcription or affecting specific protein synthesis. Protein polypeptide occupies the important position in the development of life science. In recent years, it has been widely regarded and applied to hunger.

So what is the history of the polypeptide industry? Today I'm going to take you through the annals of the development of peptides

In 1902, London university school of medicine in two physiologist Bayliss and Starling in the human body for the first time showed that peptides (pancreatic gastrin-releasing), because of its influence is extremely profound, the Nobel committee awarded Nobel Prize in physiology, at this point, peptides appeared officially in scientific research, and laid the foundation for after long development.

In 1931, scientists discovered a neuropeptide called Substance P that excites smooth muscles and relaxes blood vessels, lowering blood pressure.

In 1952, biochemist Stanley Cohen discovered that a polypeptide called nerve growth factor (NGF) was responsible for the accelerated growth of sympathetic nerve fibers and the apparent enlargement of the ganglion in mice.

In 1953, a biochemical group led by Vigneand completed the first bioactive peptide-catalyzed peptide synthesis.

In 1958, Dr. Herber Boyer, an American Jewish biochemist and professor at the University of California, Used cell recombination technology to successfully develop the active polypeptide (HGH) for 38 years, which controlled the quantity, quality and speed of protein synthesis. It controls disease and aging. He was awarded the Nobel Prize in biology that year for his discovery of the active peptide and its effects.

In 1965, Chinese scientists completed the synthesis of crystalline bovine insulin, which was the world's first artificial synthesis of peptide bioactive substances, the insulin is 51 peptide, laid the foundation for the development of the peptide industry in China.

In the 1970s, neuropeptide research reached its peak, enkephalin and opioid peptide were discovered successively, and human beings began to study the effect of peptides on the development of biological embryos.

In 1975, Huys and Kosterlitz isolated endogenous peptides from human and animal nerve tissues, opening a new field of biopharmatology called "cell growth regulators".

1987 The first genetic drug, human insulin, was approved in the United States.

In the 1990s, the Human Genome Project was launched. With the deciphering of genes, the research and application of polypeptides are flourishing. It has been found that all the life phenomena of gene expression are presented by proteins. Genes are the information instructions for synthesizing proteins, but all the physiological activities of the human body ultimately need proteins to complete. So scientists turned their attention to another big project in bioengineering: proteomics.

In 1990, Dr. Rudman(Rodman) formally proposed the HGH theory to explain the causes of human disease and aging, and applied HGH to the field of anti-aging and disease prevention for the first time. On April 19 of that year, the New York Times published a full-page report under the title "The Magical HGH of The Origin of Life".

Polypeptide drugs are a class of drugs with extremely rapid market growth. In the past decade, the compound growth rate is as high as 10.80%. In the next 10 years, the polypeptide market can reach us $40 billion by 2025 according to the conservative estimate of 6% compound growth rate. The 21st century is an era of bioengineering. Compared with common drugs, polypeptide drugs have a longer life cycle. Hangzhou Peptida-Jia Biotechnology Co., Ltd. is committed to the development of peptide technology and large-scale production research. At present, we have developed a variety of functional active polypeptide products and highly effective synergistic composite beauty peptide products. Hangzhou Peptide good biological to provide you with a variety of high quality peptides. If you have any needs or questions, please contact us directly.